Preheat the oven to 350ºF. In a small bowl, whisk together the egg, milk, and Worcestershire sauce. In another bowl, combine the breadcrumbs, Italian seasoning, garlic powder, salt, and pepper. Finely mince the onion.
Place the ground beef in a large mixing bowl. Add the egg mixture, breadcrumb mixture, and minced onion. Mix with your hands until everything is evenly combined, being careful not to overmix.
Transfer the meat mixture to a rimmed baking dish and shape it into a loaf about 4 inches wide, 8 inches long, and 2 inches tall.
In a separate small bowl, stir together the ketchup, brown sugar, Worcestershire sauce, and mustard to make the glaze. Spread it evenly over the top and sides of the meatloaf.
Bake for 50–55 minutes, or until the internal temperature reaches 165ºF. Let the meatloaf rest for 5–10 minutes before slicing and serving.
Notes
Ground Beef: Using 80/20 ground beef is recommended because the fat content helps keep the meatloaf moist and flavorful while baking.
Brown Sugar: The sugar balances the tangy ketchup and helps create a lightly caramelized glaze in the oven. If you prefer a less sweet topping, reduce the amount of sugar by half.
Nutrition Calories: 328 kcal | Carbohydrates: 15 g | Protein: 19 g | Fat: 21 g | Saturated Fat: 8 g | Cholesterol: 100 mg | Sodium: 676 mg | Potassium: 430 mg | Fiber: 1 g | Sugar: 3 g | Vitamin A: 300 IU | Vitamin C: 3 mg | Calcium: 40 mg | Iron: 3 mg